Abstract
Two iminodiacetate (IDA) gels were prepared by different synthetic routes: (a) direct coupling of IDA to epoxy-activated Sephadex G-25; and (b) a two-step synthesis involving initial introduction of amino groups into epoxy-activated Sephadex G-25 and their subsequent carboxymethylation. The efficiency of coupling of IDA to the epoxy-activated matrix was studied in detail as a function of pH in the range from 8.0 to 12.5. The IDA gel produced by the direct coupling procedure at the optimum pH of 10.5 was found to retain ca. 450 μmol of Cu 2+ per g dry weight. Different α-haloacids were explored as carboxymethylating agents for the second step of the two-step preparation. IDA gels produced with the use of bromoacetic acid were found to retain ca. 370 μmol of Cu 2+ per g dry weight. A novel chelating gel having a “hybrid” carboxyl/sulphonic ligand was also synthesized and its chelating properties were compared to the standard IDA gels. This gel retained only 180 μmol of Cu 2+ per g dry weight. The retention of Cu 2+ in the presence of the competing ligand, glycine, was inferior to that obtained with the IDA ligand.
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