Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes.

Abstract

A sensitive and inexpensive differential pulse voltammetric technique was applied toinvestigate the electrochemical behavior of alfuzosin hydrochloride at two different workingelectrodes: silica gel modified carbon paste and pencil graphite electrodes (PGE). Thevoltammetric conditions were optimized using cyclic voltammetry, showing an irreversibleanodic peak in Britton-Robinson buffered medium (pH 6) at 0.86-0.90 V. The electrochemicalresponses were linearly correlated with alfuzosin concentrations (R2> 0.999) in the ranges of0.6-20 and 0.3-20 μM, exhibiting higher electrocatalytic activity at PGE with a low detectionlimit/ detectability of 0.099 μM. In addition, this study was a successful attempt for the drugdetermination in tablets and spiked urine samples with green profile evaluation, employing theNational Environmental Methods Index, analytical Eco-Scale score, and Green AnalyticalProcedure Index.