Development of Efficient and Reusable Diarylphosphinopolystyrene‐Supported Palladium Catalysts for CC Bond Forming Cross‐Coupling Reactions

Abstract

AbstractShort and versatile syntheses of reusable diarylphosphinopolystyrene‐supported palladium catalysts 3a–j are described. The bis(o‐tolyl)phosphino catalyst 3b is particularly efficient for the Suzuki and Sonogashira cross‐couplings, whereas the bis(m‐tolyl)phosphino catalyst 3c is the most active catalyst for Heck reactions. The couplings are performed under non‐anhydrous reaction conditions and require only low amounts of supported palladium (0.5 mequivs. for Suzuki–Miyaura, 1.0 mequiv. for Sonogashira and 0.5 mequivs. for Heck reactions could be sufficient). Catalysts 3a–j are recovered by filtration and can be reused more than four times with no loss of efficiency.