Abstract
The effects of indapamide on the development of cardiac complications related to deoxycorticosterone acetate (DOCA)-salt-induced hypertension in guinea-pigs have been studied. Indapamide treatment (5 mg kg−1 daily) was initiated either before DOCA administration or five weeks after DOCA administration, for a period of five weeks. Increase in blood pressure was prevented or attenuated by indapamide (−19%, P<0·05). In parallel, development of cardiac hypertrophy assessed by an increase in left ventricular weight, thickness and volume was also prevented (−13, −25 and −25%, respectively, all P<0·05) or attenuated (-7·5, −15%, P<0·05 and −9·8%, respectively). DOCA-salt treatment over a longer period (10 weeks) led rapidly to the appearance of signs of heart failure with pleural or pericardial effusion. Indapamide-treated guinea-pigs presented no such signs of heart failure. These results demonstrate that the DOCA-salt guinea-pig is a suitable model for studying hypertensive disease. Indapamide prevents and produces a regression in hypertension and cardiac hypertrophy, and prevents the development of heart failure.
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