Development of Diffuse Large B-Cell Lymphoma and Sarcoidosis In The Course Of Multiple Myeloma: A Case Report with Literature Review

Abstract

Despite significant survival increment due to treatment improvement, multiple myeloma (MM) remains an incurable disease. We herein describe a unique patient that is not only a MM long survivor despite adverse features, such as the occurrence of extramedullary disease at relapse, but also developed, sixteen years after MM diagnosis, an extranodal diffuse large B-cell lymphoma (DLBCL) of the small intestine. The patient eventually achieved cure but developed sarcoidosis two years later that regressed with corticosteroids. Today, after 26 years of follow-up the patient is in remission and in good clinical condition.