Development of CsPbBr3 fluorescence molecularly imprinted nanoprobe for highly sensitive detection of sulfapyridine

Abstract

Molecularly imprinted fluorescent nanoparticles offer great potential in highly selective and sensitive detection of small molecules. Herein, a novel molecularly imprinted fluorescence nanoprobe polymer (CPB-Si-MIP) was successfully synthesized using CsPbBr3 perovskite nanocrystals (CPB PNCs) and a silane coupling agent via the ligand-assisted reprecipitation (LARP) approach, sol–gel method, and molecular imprinting technology (MIT). The results demonstrated a significant quenching of fluorescence in the CPB-Si-MIP nanoprobe with the sulfapyridine (SPD) template molecule. The linear range of SPD detection was found to be 20–100 ng/mL, with a low detection limit of 6.5 ng/mL. Furthermore, the imprinting factor (IF) of the nanoprobe was 2.50, highlighting its high specificity and recognition ability toward SPD as the target molecule.