Abstract
The goal of designing sustained release drug delivery systems of tablets is to reduce the frequency of dosing or to increase the effectiveness of the drug by localization at the site of action, reducing the dose required, or providing controlled drug delivery. The oral route is considered as the most promising route of drug delivery. Effective oral drug delivery may depend upon the factor such as gastric emptying process, gastrointestinal transit time of dosage form. Most of the oral dosage forms possess several physiological limitations such as variable gastrointestinal transit, because of variable gastric emptying leading to non-uniform absorption profiles, incomplete drug release and shorter residence time of the dosage form in the stomach. This lead to incomplete absorption of drug having absorption window especially upper part of small intestine, as once the drug passes down the absorption site the remaining quantity goes down unabsorbed.
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