Abstract
Surface-enhanced Raman scattering (SERS) has been intensely researched for many yearsas a potential technique for highly sensitive detection. This work, through the reduction ofHAuCl4 with pyrrole in aqueous solutions, investigated a facile one-pot synthesis of flower-like Aunanoparticles with rough surfaces. The formation process of the Au nanoflowers (AuNFs)was carefully studied, and a spontaneous assembly mechanism was proposed based on thetime-course experimental results. The key synthesis strategy was to use pyrrole as a weakparticle stabilizing and reducing agent to confine crystal growth in the limited ligandprotection region. The nanometer-scale surface roughness of AuNFs provided several hotspots on a single particle, which significantly increased SERS enhancement. Goodbiocompatible stable Raman-active probes were synthesized by coating AuNFs withchitosan. The conservation of the SERS effects in living cells suggested that thechitosan-capped AuNFs could be suitable for highly sensitive detection and have potentialfor targeting of tumors in vivo.
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