Development of Bile Direct Stent Having Antifouling Properties by Atmospheric Pressure Low-Temperature Plasma

Abstract

Biomimetics (or biomimicry) is a field of technologies based on imitating various functions and properties of organisms. Waterproof products, which are inspired by lotus leaves with super-water-repellent fine structures, are a well-known example of biomimetics. The present study examined the surface structure of snail shells, which exhibit oil repellency (oleophobic property). Snail shells have nanoporous structures with nanoholes on the scale of 200–400 nm. When water enters these nanoholes, the surface is covered by thin water films. The oil can be repelled by the water film. These structures are known as superhydrophilic nanostructures. An earlier report discussed our efforts to create such nanostructures using a nanoimprinting method and assessed the feasibility of application to the inner walls of biliary stents. This involves a labor-consuming two-stage process involving creating nanostructures on a film surface, then rolling the film into a tube. In addition, the nanoimprinting mold made via electron beam lithography is costly and unsuitable for mass production.To overcome these issues, we sought to develop elemental technologies for providing antifouling properties to biliary stents, which are made of polyethylenes (PEs), by forming nanostructures directly on the inner surface, using atmospheric pressure low-temperature plasma. We formed nanostructures on the inner walls of PE tubes of varying diameters under varying plasma conditions. We then examined the resulting structures and effects of the antifouling properties thus imparted.