Abstract
In healthcare, accurate detection of biomarkers is paramount for disease diagnosis, prevention, and personal health surveillance. This study focused on developing and validating a MgCl2 deposited hollow microneedle array integrated with a dual-functional sensor system, which was used for osmosis-assisted boosted interstitial fluid extraction, the simultaneous and continuous monitoring of urea and pH in interstitial fluid. The urea sensor component was fabricated by electro-depositing prussian blue onto a carbon electrode, followed by applying a molecularly imprinted polymer layer, ensuring high specificity and sensitivity. The pH sensor was constructed through electropolymerization of polyaniline, exhibiting a linear response across a wide pH range. When tested in artificial skin matrix, the system demonstrated excellent in vitro electrochemical sensing performance with high linearity and repeatability. At the same time, the practical in vivo sensing performance of the system was verified in Sprague-Dawley (SD) rats. The development of the system underscores its potential as a valuable tool for continuous health monitoring.
Published Version
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