Abstract
Abstract Introduction Device-related thrombus (DRT) remains a significant complication after left atrial appendage occlusion (LAAO) and is associated with device position. Clinical prospective study of the influence of device position on DRT is cumbersome. Purpose To establish an in vitro bench test platform that allows visual, transesophageal echocardiographic and color Doppler hemodynamic assessments of left atrial appendage occlusion devices. Methods Based on a mock circulatory system, an in vitro platform was developed to create pathophysiological environment and left atrium wall motion under atrial fibrillation condition. Results LAAO devices could be visualized in the left atrium phantom model using transesophageal echocardiography and color Doppler measurement of local blood velocity at LAAO devices were proven to be capable. Deep implantations resulted in uncovered left upper pulmonary vein ridges. In comparison to ostium-fitted device positions, deep implantations were associated with reduced velocity of blood and the local velocity in the "cul-de-sac" remained lower than the critical threshold of 0.2 m/s. Conclusions An in vitro platform was developed that allows transesophageal echocardiographic and color Doppler hemodynamic assessments of left atrial appendage occlusion devices.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call