Abstract
A new Simple, sensitive and accurate spectrophotometric methods have been developed for the determination of loratadine (LOR) drug. This method based on the reaction of (LOR) with Prussian blue, it is prepared by reaction of ferrous sulfate and potassium ferrocyanide with KI+KIO4 solution. The product shows absorption maximum at 460 nm. The linearity ranges of LOR are (2-18 µg.mL-1) with molar absorptivity (19373.728 liter. mol−1.cm−1 and the Sandell's sensitivity index 0.01976 µg/cm2) detection of limit and Quantification limit (0.123, 0.375 µg / mL) respectively. The results showed that there are no interferences of excipients on the determination of the drug. The proposed method has been successfully applied for the determination of Loratadine in pure and pharmaceutical formulations.
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