Abstract
A simple, sensitive, rapid and accurate spectrophotometric method was developed for the determination of risedronate, a bisphosphonate drug important for the treatment of a variety of bone diseases, in raw material and pharmaceutical formulations. The proposed method is based on complex formation between risedronate and Cu (II) ions in acetate buffer of pH5.5. The optimum conditions for this reaction were ascertained and a spectrophotometric method was developed for the determination of risedronate in concentration range of 2-40 µg/mL with detection limit of 0.03 µg/mL (9.51 × 10-8 mol/L). The molar absorbtivity was 8.00 × 103 l/mol/cm. The method was successfully applied for the determination of risedronate in tablet dosage form with mean percentage recovery of 101.04 ± 0.32. The results obtained were favorably compared with those obtained by the comparison method. Furthermore, the proposed method was applied for content uniformity testing of risedronate tablets.
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