Abstract
ABSTRACTIn presented work Alginate-Neusilin US2 micro-composite beads (MCBs) were formulated and optimized for oral delivery of cilnidipine (CIL). Optimized formulation of CIL loaded MCB (BA-O) exhibits particle size (1.55 ± 0.05mm), entrapment efficiency (82.35 ± 1.5%), and drug release after 12h (69.27 ± 2.2%). In vitro drug release indicates sustained drug release behavior following anomalous diffusion mechanism. The desirability function helps in formulating a new formulation with desired values of response. Furthermore, multiple linear regression analysis (MLRA) helps to predict influence of independent variables on dependent variables. The optimized MCB can be sorted as novel approach for sustaining CIL release profile to get maximum health benefits.
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