Abstract
The acute effects of medial (VMH) and lateral (LH) hypothalamic lesions on stomach morphology, motor activity, and feeding behavior were compared in two experiments. Rats received VMH or LH lesions and were sacrificed 4, 8, or 24 h later. Both lesions produced high activity counts at 4 h and a comparable number of ulcers, starting at the earliest interval tested. Neither VMH nor LH lesions produced acute changes in other organs, such as the adrenals, thymus, or spleen. In a second experiment, quantitative measures of stomach pathology did not indicate significant differences between ulceration produced by VMH and LH lesions in 24 h. A separate group receiving VMH lesions showed pronounced hyperphagia and hyperdipsia immediately after the lesion, while LH rats were aphagic and adipsic. Motor activity levels after the lesions correlated positively with ulcer incidence and severity. Possible relations between these acute behavioral and visceral effects of hypothalamic lesions are discussed.
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