Abstract
Based on monolithic osmotic pump, aceclofenac tablet for controlled drug release system was developed to deliver the drug in a zero order kinetic mode. These osmotic tablets containing 100 mg Aceclofenac were prepared and coated with microporous membrane. The Osmotic Controlled Tablets (OCT) was prepared by using variables like osmogen and osmopolymer. All the tablets were examined and evaluated for physical parameters as well as the in vitro drug release characteristics, studied on USP dissolution apparatus II in 0.1N HCl and phosphate buffer pH 6.8. The drug releases from OCT were found to be dependent on types of osmogens and osmopolymer. All the formulations showed prolonged and controlled aceclofenac release. Sodium chloride based formulation exhibit slightly higher rate and extent of drug release than potassium chloride. Pectin and sodium chloride based tablets offered high push significantly due to higher osmotic pressure.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
