Development of a quantitative test detecting hearing loss using neuromagnetic cortical activity

Abstract

Event Abstract Back to Event Development of a quantitative test detecting hearing loss using neuromagnetic cortical activity Bong-Soo Kim1*, June S. Kim2, Chun K. Chung2 and Yoshinori Uchikawa3 1 Seoul National University Hospital, MEG Center, South Korea 2 Seoul National University College of Medicine, MEG Center, Department of Neurosurgery, South Korea 3 Tokyo Denki University, Japan Objective: Pure tone audiometry is a standard test measuring hearing level. However, it depends on the subject’s response mandating cooperation of the subject. Uncooperative subjects make the test time-consuming and misleading as well. Hence other objective tests are needed. The aim of this study is to develop an objective and quantitative test measuring hearing level using neuromagnetic cortical response. We used N1m and P2m component of auditory evoked field for quantifying hearing level using sound stimuli having different frequencies. Method: Eight healthy subjects and one high frequency hearing loss patient participated in AEF measurement. Auditory stimulation was tone burst sounds with carrier frequencies of 250, 500, 1000, 2000 and 4000 Hz. Sound stimulation was presented to the left ear in all subjects. The intensity of each tone burst was set to 80 dB SPL. Source locations of N1m and P2m components with equivalent current dipole method were estimated. We calculated a quantitative parameter of hearing level using amplitude ratio of N1m and P2m in each stimulus frequency. Results: The parameter in normal subject was concentrated in a narrow area, whereas the calculated parameter in the patient was distributed in a wide area. In low stimulus frequencies (250, 500, and 1000Hz), the distribution of the calculated parameter showed a similar pattern between normal subjects and the patient. However, the distribution of the parameter showed a different pattern in high frequencies (2000 and 4000Hz), where the patient had a hearing loss. The sources of the N1m components in each normal subject were localized to the auditory cortex. Meanwhile the source of the N1 component at hearing loss frequencies could not be localized to the auditory cortex in the patient. Conclusion: We confirmed that the proposed method is useful to provide objective information regarding hearing level. We will apply this method to determine hearing level of uncooperative subjects. Conference: Biomag 2010 - 17th International Conference on Biomagnetism , Dubrovnik, Croatia, 28 Mar - 1 Apr, 2010. Presentation Type: Poster Presentation Topic: Sensory Processing and Functional Connectivity Citation: Kim B, Kim JS, Chung CK and Uchikawa Y (2010). Development of a quantitative test detecting hearing loss using neuromagnetic cortical activity. Front. Neurosci. Conference Abstract: Biomag 2010 - 17th International Conference on Biomagnetism . doi: 10.3389/conf.fnins.2010.06.00227 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 31 Mar 2010; Published Online: 31 Mar 2010. * Correspondence: Bong-Soo Kim, Seoul National University Hospital, MEG Center, Seoul, South Korea, kimbs3@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Bong-Soo Kim June S Kim Chun K Chung Yoshinori Uchikawa Google Bong-Soo Kim June S Kim Chun K Chung Yoshinori Uchikawa Google Scholar Bong-Soo Kim June S Kim Chun K Chung Yoshinori Uchikawa PubMed Bong-Soo Kim June S Kim Chun K Chung Yoshinori Uchikawa Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.