Abstract
The aim of this study was to create a surgical guide platform that maintains its integrity while the surgeon performs an intestinal anastomosis or another similar procedure, which then breaks apart and is eliminated from the body in a controlled manner. The device contains mixed polymeric structures that give it a controlled rate of disassembly that could meet the requirements of a specific surgical purpose. The intraluminal anastomotic guide was manufactured as a hollow cylinder composed of layers of porous polyurethane/PCL with polyvinylpyrrolidone as the binding agent similar to a “brick–mortar” architecture. This combination of polymeric structures is a promising manufacturing method from which a variety of tunable devices can be fabricated for specific medical procedures and site-specific indications. The guide was designed to rapidly disassemble within the intestinal lumen after use, reliably degrading while maintaining sufficient mechanical rigidity and stability to support manipulation during complex surgical procedures. The nature of the device’s disassembly makes it suitable for use in hollow structures that discharge their contents, resulting in their elimination from the body. A swine model of intestinal anastomosis was utilized to validate the use and function of the device.
Highlights
The aim of this study was to create a surgical guide platform that maintains its integrity while the surgeon performs an intestinal anastomosis or another similar procedure, which breaks apart and is eliminated from the body in a controlled manner
An intraluminal guide for intestinal anastomosis was chosen to be the platform’s first-generation device because intestinal anastomosis is a common procedure generally associated with significant morbidity r ates[2–8]. Performed in both human and veterinary patients, intestinal resection and anastomosis have a variety of indications, including obstruction, such as from foreign bodies, pathologic strictures, or chronic constipation; 1Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock, Little Rock, AR, USA. 2NuShores Biosciences LLC, Little Rock, AR, USA. 3Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA. 4Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA. 5These authors contributed : Karrer M
Our results clearly indicate that the newly developed anastomotic guide (AG) does degrade in the desired timeframe and that all its components are eliminated from the animals without any complications
Summary
The aim of this study was to create a surgical guide platform that maintains its integrity while the surgeon performs an intestinal anastomosis or another similar procedure, which breaks apart and is eliminated from the body in a controlled manner. The intraluminal anastomotic guide was manufactured as a hollow cylinder composed of layers of porous polyurethane/PCL with polyvinylpyrrolidone as the binding agent similar to a “brick–mortar” architecture This combination of polymeric structures is a promising manufacturing method from which a variety of tunable devices can be fabricated for specific medical procedures and site-specific indications. An intraluminal guide for intestinal anastomosis was chosen to be the platform’s first-generation device because intestinal anastomosis is a common procedure generally associated with significant morbidity r ates[2–8]. Performed in both human and veterinary patients, intestinal resection and anastomosis have a variety of indications, including obstruction, such as from foreign bodies, pathologic strictures, or chronic constipation; Scientific Reports | (2022) 12:3208. Despite medical advancements, including automated devices, these complications p ersist[12]
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