Abstract

Neurological tumors have diverse etiologies and treatments. Presently, diagnostic technologies such as MRI or CT scans are limited by poor resolution, and thus imprecise identification of tumor classes. As a result, diagnostic methods rely on highly invasive intracranial biopsies for conclusive tumor identification. Development of non-invasive methods to accurately identify tumor class may lead to earlier and more accurate diagnoses, enabling prompt and targeted treatment strategies. To address this unmet clinical need, we report the development a molecular-recognition-based nanosensor array that can accurately identify a molecular fingerprint of glioma and meningioma from plasma. We developed this capability using sensor arrays of chemically modified carbon nanotubes that can transduce subtle differences in the physicochemical properties of molecules in biofluids via sensitive molecular binding interactions. Using high-throughput near-infrared fluorescence spectroscopy, we screened 23 chemically modified (6,5) carbon nanotubes sensors in 324 patient plasma samples. We trained machine learning models to classify sensor responses as coming from either glioma or meningioma tumors. The best performing models were able to achieve a positive predictive value of 0.75. Sensor feature analysis revealed a set of spectral features positively associated with class differentiation. This work has the potential to aid clinical care by facilitating the early triage of different types of tumors to provide better treatment options for patients.

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