Abstract
The TNFα receptor is a major therapeutic target since over production of TNFα plays a key role in the development of septic shock following bacterial infection and has been implicated in the pathogenesis of many inflammatory disorders such as rheumatoid arthritis. To screen our NATCHEMTM Libraries for novel natural product inhibitors of this target we have developed a sensitive immobilised TNFα receptor binding assay based on a commercially available recombinant soluble TNFα receptor (p55) and [125I]-TNFα.
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