Development of a novel nanosensor using Ca-doped ZnO for antihistamine drug

Abstract

Electrochemical practices have showed more sensitivity compared to other techniques for the finding of organic molecules including drugs and related molecules in pharmaceutical tablets and biological matters considering their oxidizable attributes. Nanosensors have achieved enormous recognition from researchers as of their exceptional electrocatalytic properties and applications in diverse areas over the previous few years. The present study deals with a development of a nanosensor for the electroanalysis of methdilazine (MDH) at calcium doped zinc oxide nanoparticle adapted glassy carbon electrode (Ca–ZnO/GCE) utilizing techniques such as square wave voltammetry (SWV), linear sweep voltammetry (LSV), and cyclic voltammetry (CV) in pH 10.4 phosphate buffer (PB) solution of 0.2 M ionic strength. The synthesized ZnO and Ca-doped ZnO nanoparticles were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) analysis. The semiconducting characters of doped nanoparticles showed increment in the peak response at Ca–ZnO/GCE compared to bare glassy carbon electrode (GCE). The parameters such as aggregation time, scan rate, pH, and strength of analyte variation were premeditated in order to find out the type of process, electrons involved count, detection and quantification limit of MDH, etc. The application of the developed sensor was studied by quantifying MDH in clinical and urine samples. The results found to be more accurate with good recovery values.