Abstract
In this study, we produced a novel chemical cross-linked Guar gum/Poly(methylvinylether-alt-maleicacid) (GG/PMVE-MA) hydrogels with various blending weight ratio of GG, and PMVE-MAn (GG/P20, GG/P40, and GG/P70). These produced hydrogels were analyzed by Fourier-transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), thermogravimetric analysis (TGA), swelling degree, and mechanical characteristics. The results demonstrated that with increasing PMVE-MAn content, thermal stability, swelling degree, and mechanical characteristics of hydrogels were improved. As a result, the GG/P70 hydrogel was selected as an optimal hydrogel. Moreover, MTT analysis indicated that these hydrogels were non-toxic and any reduction or stop of cells growth wasn't observed over time. Additionally, encapsulation of cinnamaldehyde (CA)-loaded chitosan nanoparticles (CSNPs) into optimal hydrogel formulation significantly (P < 0.05) increased scavenging of 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical about 60%. In addition, the inhibition capability of GG/P70/CA-loaded CSNPs hydrogel against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), demonstrating that the hydrogel had high antibacterial and antioxidant activities. The general results showed that this composite hydrogel (GG/P70/CA-loaded CSNPs) could be useful for various applications such as drug delivery, tissue engineering and food industry.
Highlights
Biopolymer-based hydrogels have been extensively identified as biomaterials due to their high biocompatibility, safety, bioactivity, and biodegradability [1,2,3,4]
The results demonstrated that with increasing PMVE-MAn content, thermal stability, swelling degree, and mechanical characteristics of hydrogels were improved
This paper presents a scientific report of developed GG/poly [methylvinylether-alt-maleic acid] (PMVE-MA)/CA-loaded CS nanoparticles (CSNPs) composite hydrogels for use in different industrial applications
Summary
Biopolymer-based hydrogels have been extensively identified as biomaterials due to their high biocompatibility, safety, bioactivity, and biodegradability [1,2,3,4]. The main limitation of GG for hydrogel fabrication is its high hydrophilic properties, and reduction in viscosity [12, 13]. These limitations of GG can be overcome by combining it with a synthetic/semi synthetic polymer, and chemical modification to produce an effective hydrogel [14]. Thereby, choosing the suitable synthetic polymer to overcome the limitations of GG is important
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