Abstract
Development of a New Method for the Determination of Manganese, Cadmium, Mercury and Lead in Whole Blood and Amniotic Fluid by Inductively Coupled Plasma Mass Spectrometry
Highlights
The increasing pollution originated from industrialisation exposes the entire population to several toxic agents such as heavy metals, organic hydrocarbons, and pesticides [1]
Blood is the medium for the transport of essential and toxic trace elements and is collected, and the analysis of these elements in blood has become a routine procedure as a measure of pollution [4,7]
The aim of this study was to develop a method for the simultaneous determination of Pb, Hg, Cd and Mn in whole maternal blood and amniotic fluid by inductively coupled plasma-mass spectrometry (ICP-MS)
Summary
The increasing pollution originated from industrialisation exposes the entire population to several toxic agents such as heavy metals, organic hydrocarbons, and pesticides [1]. Environmental exposure to metals among women, revealed their adverse effects on pregnancy During this stage, blood levels of some metals increase because of an increase in bone turnover and increased gastrointestinal absorption or other unknown mechanisms [3]. These elements can be commonly found in the environment and in food They are often present as pollutants in the environmental compartments as a result of uncontrolled anthropogenic activities, resulting in the accumulation of these elements in human tissues [4,5]. Determinations of these trace elements in human fluids have been used to obtain information on nutritional status for the diagnosis of diseases, indication of systemic intoxication, and to obtain information on environmental exposure. The early exposure to Pb, Hg, and Cd has been correlated to infant health effects, such as neurological, developmental, and endocrine disorders [1]
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