Abstract

In this work, a novel stirrer-assisted liquid-phase microextraction method using switchable hydrophilic solvents was developed for the extraction and preconcentration of bisphenol A from real samples prior to electrochemical analysis. For the first time, the effect of stirring while switching the extraction solvent (N,N-dipropylamine, DPA) was investigated, and the use of stirring instead of temperature change, which is a time-consuming process, hazardous acids (e.g., HCl), and dry ice was used for bisphenol A extraction based on switchable solvents. Various parameters such as solvent type, solvent volume, stirring time, and stirring speed were optimized. The optimized conditions were 100 μl DPA, 2 min extraction time, 30 s stirring time, 700 rpm stirring speed, and solution pH of 7.0. A theoretical study was also conducted to show the effects of stirring on the homogenization of the phases. The proposed method offers some advantages, such as simplicity, use of a small amount of inexpensive and less hazardous reagents, rapid extraction, and shorter analysis time. Under the optimized conditions for the developed method, LOQ and LOD were obtained to be 0.01 and 0.003 μM, respectively. Moreover, the calibration curves were linear in the range of 0.01–250 μM. The proposed method was used for the determination of bisphenol A in food and water samples.

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