Development of a Nanofabricated Sensor for Monitoring Intraocular Pressure via Ocular Tissue Strain.

Abstract

As the number of individuals developing glaucoma is increasing, researchers and ophthalmologists are exploring new approaches to monitor intraocular pressure, which is a critical measurement for glaucoma detection. Current monitoring methods, such as implantable pressure sensors and wearable contact lenses with sensors, are being explored in eye research clinics. However, these systems currently lack in providing 24 hours data through a practical platform for large-scale use. This paper presents a novel method that provides constant measurements of the scleral strain, which is correlated with the change of intraocular pressure, using a nanofabricated discrete resistor array implant sensor. A preliminary bench-top test was performed using the sensor, and it showed that the nanofabricated 1.6 mm by 2.7 mm resistor array exhibits discrete sensing levels at increments of 41 ohms as a fixture needle traversed approximately half of the array. Though the nanosensor is in the prototype developing stage, it promises a new modality for constant, remote, and around the clock glaucoma monitoring.