Abstract
A multimodal endomicroscope was developed for cancer detection that combines hyperspectral and confocal imaging through a single foveated objective and a vibrating optical fiber bundle. Standard clinical examination has a limited ability to identify early stage oral cancer. Optical detection methods are typically restricted by either achievable resolution or a small field-of-view. By combining high resolution and widefield spectral imaging into a single probe, a device was developed that provides spectral and spatial information over a 5 mm field to locate suspicious lesions that can then be inspected in high resolution mode. The device was evaluated on ex vivo biopsies of human oral tumors.
Highlights
Detection of oral squamous cell carcinoma (SCC), the most common type of head and neck cancer, is critical to improve patient outcomes
Detection of oral cancer is facilitated by clinical oral examination (COE), where a trained physician performs visual inspection and palpation of the head and neck regions to evaluate the oral mucosa for abnormal changes such as leukoplakia and erythroplakia; biopsy is required to confirm the presence of disease [2,3]
In this work we present a probe that combines a high resolution confocal microscope with widefield multispectral imaging through a single foveated endomicroscope
Summary
Detection of oral squamous cell carcinoma (SCC), the most common type of head and neck cancer, is critical to improve patient outcomes. The oral cavity is simple to access and inspect for frequent screening, cancers are often discovered at a late stage when treatment options are more invasive and less effective. Oral examination should be trivial due to the ease of access of the orifice, around 65% of oral cancers are detected at a later stage, when treatment options become more limited [2]. Detection of oral cancer is facilitated by clinical oral examination (COE), where a trained physician performs visual inspection and palpation of the head and neck regions to evaluate the oral mucosa for abnormal changes such as leukoplakia and erythroplakia; biopsy is required to confirm the presence of disease [2,3]. In an effort to improve upon the sensitivity and specificity of COE, several imaging techniques have been developed to improve the contrast between early neoplastic lesions and surrounding normal or benign tissue, with the goal of improving early detection while reducing the time and cost to obtain unnecessary biopsies
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