Abstract
BackgroundWe report development of a group-based lifestyle intervention, Let's Prevent, using the UK Medical Research Council (MRC) framework, and delivered by structured education to prevent type 2 diabetes mellitus (T2DM) in people with impaired glucose regulation (IGR) in a UK multi-ethnic population.MethodsDiabetes Education and Self-Management for Ongoing and Newly Diagnosed (DESMOND) is the first national T2DM programme that meets National Institute for Health and Care Excellence criteria and formed the basis for Let's Prevent. An iterative cycle of initial development, piloting, collecting and collating qualitative and quantitative data, and reflection and modification, was used to inform and refine lifestyle intervention until it was fit for evaluation in a definitive randomized controlled trial (RCT). The programme encouraged IGR self-management using simple, non-technical language and visual aids.ResultsQualitative and quantitative data suggested that intervention resulted in beneficial short-term behaviour change such as healthier eating patterns, improved health beliefs and greater participant motivation and empowerment. We also demonstrated that recruitment strategy and data collection methods were feasible for RCT implementation.ConclusionsLet's Prevent was developed following successful application of MRC framework criteria and the subsequent RCT will determine whether it is feasible, reliable and transferable from research into a real-world NHS primary healthcare setting.Trial RegistrationISRCTN80605705.
Highlights
We demonstrated that recruitment strategy and data collection methods were feasible for randomized controlled trial (RCT) implementation
Screening studies carried out in primary care in the UK1 have shown that screening for type 2 diabetes mellitus (T2DM) will identify around 15% of middle aged adults with impaired glucose tolerance or impaired fasting glucose, collectively termed impaired glucose regulation (IGR) and known as pre-diabetes mellitus.[2]
We demonstrate in this article how the Medical Research Council (MRC) framework criteria were used to develop a group-based lifestyle intervention known as Let’s Prevent to prevent T2DM in people identified as being ‘at risk’
Summary
Screening studies carried out in primary care in the UK1 have shown that screening for type 2 diabetes mellitus (T2DM) will identify around 15% of middle aged adults with impaired glucose tolerance or impaired fasting glucose, collectively termed impaired glucose regulation (IGR) and known as pre-diabetes mellitus.[2]. Project Support Manager Heather Daly, Professor and Nurse Consultant Lorraine Martin Stacey, Diabetes Nurse Specialist Margaret A. Senior Research Fellow Naina Patel, Research Associate Kamlesh Khunti, Professor of Primary Care Diabetes and Vascular Medicine Thomas Yates, Reader in Physical Activity, Sedentary Behaviour and Health Laura J. We report development of a group-based lifestyle intervention, Let’s Prevent, using the UK Medical Research Council (MRC) framework, and delivered by structured education to prevent type 2 diabetes mellitus (T2DM) in people with impaired glucose regulation (IGR) in a UK multi-ethnic population
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