Abstract
Background/Aims: Because longer and/or more frequent dialysis has potential clinical benefits, home hemodialysis (HHD) systems should provide flexible renal replacement therapies. We propose a new cold dialysate regeneration system that requires 10 l per treatment for HHD. Methods: We designed a dialysate regeneration system using cold dialysate and 2 activated carbon columns alternatively switched between adsorption and desorption. Urea adsorption ratios were compared in three different conditions; cold dialysate (5.7°C), normal dialysate (36.8°C), and cold dialysate with washing. In vivo tests (n = 8) were conducted to validate this system. Results: The urea removal ratios were 20.0 ± 1.7% in cold dialysate, 36.0 ± 1.7% in normal dialysate, and 82.5 ± 1.2% in cold dialysate with washing. In animal experiments, the urea reduction ratio was 60.9 ± 6.3%, Kt/V was 1.0 ± 0.2, and serum electrolytes remained stable. Conclusion: The proposed cold dialysate regeneration system using a small volume of dialysate will be useful for HHD.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
