Development of a clinical risk score to predict resistance to intravenous immunoglobulin in children with Kawasaki Disease

Abstract

Background: Kawasaki Disease (KD) is an acute multisystem vasculitis predominately affecting young children that may lead to coronary artery abnormalities (CAA) if untreated. Current standard treatment of KD in North America is a single 2g/kg dose of intravenous immunoglobulin (IVIG); however, 10-20% of IVIG-treated children do not respond to primary treatment. The Kobayashi score (KS) is a clinical prediction model developed in Japan that identifies patients at …