Abstract
Mechanical stimulation plays a role in improving cell growth in the skeletal system. Many studies have reported the development of bioreactors to stimulate cell-seeded, three-dimensional scaffolds. In this study, we developed a bioreactor capable of applying controlled compression to a cell-seeded agarose hydrogel. This bioreactor consists of a circulation system and compression system. In the circulation system, the culture chamber was sealed to prevent contamination and a pump circulated the medium. In the compression system, mechanical stimuli were controlled by LabVIEW software and a mechanical transfer system. To compare the effects of mechanical stimulation on agarose hydrogel scaffolds, we cultured MC3T3-E1 cells statically and dynamically. The number of cells was increased by 43% at seven days under the intermittent condition than under the static conditions.
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