Abstract
Purpose of Review The muscle is separated from tendons by a specialised basement membrane that acts as the structural interface of the myotendinous junction (MTJ). In zebrafish, the larval MTJ forms at the vertical myosepta, which separate the individual myomeres that arise during somitogenesis. In this review, we examine the formation of the vertical myosepta in zebrafish. We then describe insights this gains us in the context of muscle basement membrane failure, the mechanistic basis of the inherited muscle wasting condition muscular dystrophy (MD).
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