Abstract
Introduction: A new, simple, precise, accurate, and reproducible method was developed and validated for the simultaneous estimation of Metformin Hydrochloride (MH) and Pravastatin Sodium (PS) in pure form.
 Methodology: Simultaneous estimation of Metformin Hydrochloride (MH) and Pravastatin Sodium (PS) was estimated by ultraviolet (UV) spectrophotometry using the absorbance subtraction method. The method was based on the measurement of absorbance at two wavelengths 232 nm and 238 nm, of metformin and Pravastatin Sodium respectively. These studies were performed at three different levels (75%, 100%, and 125%) and the % recovery of MH and PS was calculated.
 Results: The LOD and LOQ were found to be 0.481 μg/ml and 0.670μg/ml for MH and 1.15μg/ml and 1.68μg/ml for PS respectively. All the statically analyses were within the standard limits. It proves that the method was repeatable and selective for the simultaneous.
 Conclusion: Therefore, the present study concludes that it can be successfully used for simultaneous estimation of MH and PS in pure and pharmaceutical dosage forms. The developed method was found to be simple, precise, and accurate.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call