Abstract
Objective: A new, simple, rapid, accurate and economical method have been developed for the simultaneous estimation of Metformin HCl and Repaglinide in formulation. Method: The absorbances of both the drugs were determined at 238 nm and at 294 nm. The linearity was observed in the concentration range of 2-100 µg/ml and 1-35 µg/ml for Metformin HCl and Repaglinide respectively. The method was validated as per ICH guidelines. Result: The recovery of Metformin and Repaglinide was found in the range of 98.24 ± 0.325 to 100.25 ± 0.756. Conclusion: The proposed method was accurate, reproducible and economical and can be used successfully for quantitative estimation of Metformin HCl and Repaglinide in bulk and tablet dosage form. Keyword:- Metformin, Repaglinide, UV- spectrophotometric method, simultaneous estimation
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
