Development and Validation of Qualitative and Quantitative Analytical Method for Identification and Analysis of Amphetamines by Gas Chromatography

Camargo Esther Ricci Adari,Spinosa Helenice De Souza,Trindade Rodrigo Martins P.O Da,Felgueiras André Augusto R,Fukushima André Rinaldi,Muñoz Juliana Weckx Peña,Waziry Paula A Faria,Ferreira Mônica Novaes,Pantaleon Lorena De Paula,Zaim Marcella

doi:10.23937/2474-3631/1510032

Camargo Esther Ricci Adari, Spinosa Helenice De Souza + Show 8 more

Open Access

https://doi.org/10.23937/2474-3631/1510032

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Abstract

Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by peripheral blood cytopenias, with associated morphologic dysplasias, and recurrent cytogenetic abnormalities. However, approximately 40-50% of MDS have no detectable cytogenetic abnormalities or cytogenetically-normal (CN-MDS). MDS cases with concurrent cytogenetics/FISH and molecular testing were identified from a two-year cohort with a median time to follow-up of 506 days. A total of 153 MDS were gathered, and we identified 58 patients with CN-MDS. Somatic mutations were seen in 93% of the CN-MDS patients, involving a variety of cellular pathways.

Highlights

Amphetamines have as basic structure the β-phenylisopropylamine
Standardization of our method was based on analysis of amphetamine, methamphetamine, amfepramone, methylenedioxymethamphetamine and fenproporex
Small chemical modifications of this molecule generate a large number of pharmacologically active compounds such as amphetamine, methamphetamine, methylenedioxymethamphetamine (MDMA), amfepramone (DEP), fenproporex (FEM), among others

Summary

Introduction

Amphetamines have as basic structure the β-phenylisopropylamine. Small chemical modifications of this molecule generate a large number of pharmacologically active compounds such as amphetamine, methamphetamine, methylenedioxymethamphetamine (MDMA), amfepramone (DEP), fenproporex (FEM), among others. Camargo et al Int Arch Addict Res Med 2021, 6:032 Page 1 of 7 . Ingestion of amphetamines enhances the central nervous system (CNS) activity and allows users to acquire higher levels of competence in order to perform activities for longer periods of time and with less fatigue. During the first few hours after ingestion, the user gets a sensation of well-being and disposition, but after these effects subside, they become irritable, depressed, and often overtaken by uncontrollable somnolence [3]

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