Abstract
A precise, simple, cost effective, accurate, eco-friendly and validated fourier transform infrared spectroscopy method has been developed for the simultaneous estimation of Clonidine Hydrochloride and Chlorthalidone in pharmaceutical synthetic mixture. The developed method involves measurement of spectral wavenumber of the infrared band corresponding to (–C=N) from 1658.78 cm-1 for Clonidine Hydrochloride and (-S=O) group from 1346.31 cm-1 for Chlorthalidone. Over the range of 1.5–3% w/w for Clonidine hydrochloride and 15–90% w/w for Chlorthalidone, the method was found to be linear. It has correlation coefficient (r2) of 0.999 for Clonidine hydrochloride and 0.994 for Chlorthalidone. According to ICH guidelines, in terms of accuracy, linearity, limit of detection and limit of quantitation, precision, the developed method was validated. In addition to this, degradation behaviours of Clonidine Hydrochloride and Chlorthalidone were studied by subjecting them to sunlight, photolytic and thermal degradation.
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