Abstract
This study aimed to develop spectrophotometry method by double divisor ratio spectra derivative to determine the levels of dextromethorphan hydrobromide (DEX), doxylamine succinate (DOX) and pseudoephedrine hydrochloride (PSE) in tablet dosage form using ethanol as solvent. The method is based on the use of the coincident spectra of the derivative of the ratio spectra obtained using a double divisor and measuring at the wavelengths selected. Then, the method was applied to determine the levels of DEX, DOX and PSE in tablet dosage form. The selected wavelengths for determination of DEX, DOX and PSE are 277.0 nm, 243.0 nm, and 243.2 nm, respectively. The mean % recoveries were found to be in 100.88%, 100.05%, and 100.26% for DEX, DOX and PSE, respectively. The method is successfully applied to analyze DEX, DOX and PSE in pharmaceutical formulation with no interference from excipients as indicated by the recovery study. All validation parameters were within the acceptable range.
Highlights
Dextromethorphan hydrobromide (DEX) is an antitussive agent commonly used in cough and cold preparations
Doxylamine succinate (DOX) is chemically known as N,N-dimethyl-2-[1phenyl-1-(2-pyridinyl)ethoxy]-butanedioate [2, 3]
No references have been found for simultaneous estimation of DEX, DOX and Pseudoephedrine hydrochloride (PSE) in their combined tablet dosage form by double divisor ratio spectra derivative spectrophotometry method
Summary
Dextromethorphan hydrobromide (DEX) is an antitussive agent commonly used in cough and cold preparations. DEX is chemically known as 3-methoxy-17-methyl-(9α,13α,14α) morphinan hydrobromide monohydrate [1, 2]. Doxylamine succinate (DOX) is an antihistamine used to relieve symptoms of allergy and the common cold. DOX is chemically known as N,N-dimethyl-2-[1phenyl-1-(2-pyridinyl)ethoxy]-butanedioate [2, 3]. Pseudoephedrine hydrochloride (PSE) is a nasal decongestant and as bronchodilation. PSE is chemically known as (1S,2S)-2methylamino1-phenylpropan-1-ol hydrochloride [4,5,6]
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