Abstract
The objective of present study was to develop and validate an analytical method for quantitative determination and dissolution studies of glimepiride in tablets. The glimepiride shows absorption maxima at 225 nm and obeyed Beer's law in the range of 6.0 – 14.0 µg/mL. The limit of detection and limit of quantitation were 0.06, and 0.17 µg/mL respectively. Percentage recovery of glimepiride for the proposed method ranged from 99.32 to 100.98% indicating no interference of the tablet excipients. It was concluded that the proposed method is simple, easy to apply, economical and used as an alternative to the existing spectrophotometric and non-spectrophotometric methods for the routine analysis of glimepiride in pharmaceutical formulations andin vitrodissolution studies.
Highlights
IntroductionA survey of pertinent literature revealed that few liquid chromatography [2, 3] and derivative spectrophotometry [2, 4] methods has been developed for the determination of glimepiride in pharmaceutical formulations
The aim of the present work is to develop and validate a simple UV spectrophotometric method to be applied for the quantification and dissolution studies of glimepiride in tablets, which serves as a tool for the quality control of pharmaceutical dosage forms
Glimepiride was analyzed by developed UV spectrophotometric method in tablets
Summary
A survey of pertinent literature revealed that few liquid chromatography [2, 3] and derivative spectrophotometry [2, 4] methods has been developed for the determination of glimepiride in pharmaceutical formulations. Spectrophotometry [6, 7] and Liquid chromatography [8, 9] methods have been developed for the estimation of glimepiride in combination with other drugs in pharmaceutical formulations. The aim of the present work is to develop and validate a simple UV spectrophotometric method to be applied for the quantification and dissolution studies of glimepiride in tablets, which serves as a tool for the quality control of pharmaceutical dosage forms
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