Abstract
A high-performance liquid chromatographic method was developed that separates Meldrum's acid from its primary decomposition products, malonic acid and acetone. The method uses a reversed-phase column under isocratic conditions, with detection by ultraviolet absorption at 210 nm. Quantitation of the parent molecule and the acid decomposition product was possible over concentration ranges of 0.1–10.0 and 0.1–2.0 mg/ml, respectively. Acetone could be determined only at much higher concentrations. Using the malonic acid concentration as a measure of decomposition, this method was used to determine the hydrolytic stability of Meldrum's acid and its skin penetration properties.
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