Abstract
Development and in vivo evaluation of mucoadhesive tablets of Rebapimide
Highlights
Oral administration is the most convenient, widely utilized, and preferred route of drug delivery for systemic action
Mucoadhesive tablets of rebapimide solid dispersion were prepared by wet granulation technique using different concentrations of gum Kondagagu, gum olibanum and Guar gum
The prepared tablets were evaluated for different physico-chemical properties and the results are found to be within the pharmacopoeial limits
Summary
Oral administration is the most convenient, widely utilized, and preferred route of drug delivery for systemic action. When administered orally, many therapeutic agents are subjected to extensive presystemic elimination by gastrointestinal degradation and or first pass hepatic metabolism, as a result of which low systemic bioavailability and shorter duration of therapeutic activity. Occurring polymers, being biocompatible and biodegradable, are currently extensively researched for the development of novel drug delivery systems. There are number of drugs like domperidone, ranitidne, theophylline those have narrow absorption window from upper GIT i.e. stomach. Due to short gastric resident time less than 3 hr these drug reaches the non absorbing distal parts of intestine
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