Abstract
In the present investigation an attempt has made to design mucoadhesive buccal tablets of sumatriptan succinate to improve its bioavailability. The mucoadhesive buccal tablets were prepared by wet granulation procedure using different concentration of polycarbophil and hydroxy propyl methyl cellulose K4M alone. Compatibility study of drug and polymer were performed by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Precompression property of sumatriptan succinate was evaluated to check the suitability of compression method. Postcompressional parameters such as weight variation, hardness, thickness, surface pH, in vitro drug release, ex vivo bioadhesion time, ex vivo mucoadhesive strength, ex vivo permeation study and in vivo bioavailability study of optimized formulation were evaluated. FTIR spectroscopy and DSC study revealed that there was no possible interaction between drug and polymers, because no major change in peaks were obtained. The precompression parameters were in acceptable range of pharmacopoeial specification. The surface pH of the tablets was in the range of salivary pH (6.5 to 7.5) and tablets showed good ex vivo bioadhesion time up to 10 hr which indicated good adhesive capacity of tablets. The in vitro release of optimized formulation obeyed zero order kinetics with non-Fickian anomalous diffusion mechanism. The percentage relative bioavailability of sumatriptan succinate from optimized buccal tablets was found to be 152.76 %. Buccal tablets of sumatriptan succinate were successfully prepared with improved bioavailability.
Published Version
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