Development and evaluation of interpenetrating polymer network based superporous hydrogel gastroretentive drug delivery systems (SPH IPN-GRDDS)

Abstract

Super porous hydrogels were developed to retain the drug within intestinal PH which expand rapidly in the gastric region together with its characteristics for longer time while releasing the drug at predetermined rate. The present work focuses on formulation amelioration and advancement about super porous hydrogel tablet dosage forms of esomeprazole, a proton pump inhibitor. The formulations of gastric retentive type are prepared from semi IPN super porous hydrogel (SPH) using different concentrations of two different polymers polyvinyl alcohol (PVA), chitosan (CS) and a crosslinking agent glutaraldehyde to get the desired controlled release profile. Prepared SPH was further loaded with esomeprazole and then finally powdered. The powdered material was finally compressed to prepare SPH gastro retentive tablets of esomeprazole. Pre-formulation studies conform thecompatibility between drug and selected excipients. Prepared super porous hydrogels (SPHS) were shown desired or optimized porosity, swellability, density, mechanical strength. And drug loading. Prepared gastro retentive tablets, were shown extended gastro-retention up to 18 h, with a lag time of 11–16 min. SPH tablets were exhibited programmed drug delivery (Sustained release) behavior of above 60% medication delivery up to 7 h, along with absolute drug release time was achieved in less than 12 h (FT-5 &FT-6). The obtained value of release exponent (n) 0.733, is a sign of anomalous diffusion behavior reasonably because of bulging phenomenon.