Abstract
Wound management remains a significant challenge due to complications such as delayed healing and microbial infections, particularly in the conditions like diabetes mellitus, vascular disorders, and immunosuppression. This study aimed to develop a chitosan-coated virgin coconut oil-asiatic acid-loaded nanoemulsion gel (CS-ASA-NEG) to enhance wound healing outcomes. A central composite design (CCD) was employed using Design Expert 11 software to optimize the nanoemulsion formulation, with ternary phase diagrams (TPD) evaluating stable regions for Tween 20: Span 80 (T20:S80) ratios. The optimized 4:1 ratio yielded a nanoemulsion with a globule size of 131.80±0.33nm and an entrapment efficiency (EE%) of 94.86±0.05%. Stability studies confirmed the formulation's robustness at 5°C and 25°C for 28days. The nanoemulgel was prepared using 1% carbopol gel, with a pH of 5.50±0.04 and viscosity of 16,481±0.01cP, making it suitable for topical use. Skin permeation and irritation studies indicated superior efficacy, with a maximum flux (Jmax) of 159.10±0.08μg/cm2/h, outperforming marketed gels. The formulation achieved a wound contraction rate of 99.86±0.24% by day 20, highlighting the synergistic benefits of asiatic acid, virgin coconut oil, and chitosan. CS-ASA-NEG offers a promising approach to improve wound healing.
Published Version
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