Abstract
BackgroundTo improve the therapeutic efficacy of herbs, the “Ayurveda literature- Sarangdhar Samhita” emphasized on the concept of polyherbalism. Ready to drink granules of different ayurvedic herbs that are targeting all possible mechanisms responsible to cure obesity were prepared and evaluated for their preclinical therapeutic efficacy in high-fat-diet-(HFD) induced obese rats. MethodsRats were fed an HFD (58 E% as fat) or a standard diet and administered granules (0.1 and 0.3 g/kg) for 42 days. The body weight and food intake of rats were determined weekly whereas the plasma total cholesterol (TC), glucose and triglyceride (TG) levels and organ (adipose tissue and liver) weight measured at the end of the experiment. ResultsThe result found that body and adipose tissue weight and plasma TC and TG levels were significantly lowered in 0.3 g/kg granules treated group in comparison to the HFD control group. ConclusionThe results support the traditional weight-reducing effect of the plant extracts. The combination of plant extracts demonstrated excellent weight and fat reducing effect provided rationale for usage and generates conviction among users as effective formulae for weight management and holds the potential to treat obesity.
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