Development and Characterization of Silver nanoparticles (AgNPs) using Aqueous leaves broth of Artemisia vulgaris L., and its Anti-fungal activity

Abstract

The aim of the present study is to overcome the antifungal resistance by developing silver nanoparticles from the aqueous leaf extract of Artemisia vulgaris Linn. Silver nanoparticles (AgNPs) are one of the most vital and fascinating nanomaterials among several metallic nanoparticles that are involved in biomedical application. AgNPs plays an important role in nanoscience and nanotechnology, particularly in nanomedicine. The green synthesized AgNPs can be used in the field of medicine due to their smaller particle size, increased activity and less toxicity. Artemisia vulgaris Linn. (Mugwort) is used by many tribes throughout India to treat various conditions including cold, allergies and pain. Indian Mugwort is also used as women's medicine. It also posses anti-bacterial, anti-inflammatory, anti-fungal and many more to list out. Candida albicans is responsible for a number of major diseases as well as recent cases of resistance to the many antifungal agents. Therefore, new substances should be researched as an alternative to combat such resistance. Anti-fungal activity was assessed by well diffusion method and Minimum Inhibitory Concentration (MIC) against fungal growth. Further characterisation is done by UV-VIS spectroscopy, Scanning Electron Microscopy (SEM), Zeta sizer and Zeta potential. In this present investigation reports that the enhanced antifungal activity of silver nanoparticles using aqueous leaves extract of Artemisia vulgaris Linn.