Development and Characterization of Non-Aqueous based Self Emulsifying Nano Emulsion of Curcumin

Abstract

This research presented a novel as well as an easy method for a non-aqueous based self-emulsifying nanoemulsion of hydrophobic drug. In this Non Aqueous based self nanoemulsifying drug delivery system (SNEDDS) of curcumin was prepared, and in vitro Analysis was done. Oleic acid serves as the oil phase in Curcumin SENE formulations, which also contain Tween 20. PEG 400 as co-surfactants was selected. The preliminary confirmation was done by FTIR spectra and 1603.80cm -1 [C=C], 3420.87 cm -1 [polymeric OH stretching], 1377.22 cm -1 [C=O stretching] was observed. The preformulation study was also done with excellentflow property. Melting point of curcumin was shown at the range of 180-183°C. The λ max of Curcumin was found to be at 424 nm in methanol. Highest solubility of curcumin was found in oleic acid. The primarily confirmation of nano emulsion was done by conductivity test, fluorescence test and Viscosity. Characterization of formulation was done by FT-IR, Droplet size, viscosity, drug content, % Transmittance and robustness study. The spectrum FT-IR of pure drug and self emulsifying nanoemulsion (SENE) was showing the changes.