Abstract
Pioglitazone is a poorly water soluble drug, having short biological half life (3- 5 hour) so the present study was aimed to increase the biological half life by develop a sustained release microcapsule. The microcapsules of pioglitazone hydrochloride were prepared by employing sodium alginate as a cell forming polymer and by using a different bio-adhesive polymers as carbopol, HPMC and sodium CMC in a various ratios of 1:1, 3:1, 6:1 & 9:1, by orifice ion gelation method. Scanning electron microscope photographs of samples revealed that all prepared microcapsules were almost spherical in shape and have a slightly smooth surface. The in vitro release profile of Pioglitazone hydrochloride indicates that all the batches of microcapsules showed controlled and prolonged drug release over an extended period of 10 h. FT- IR spectra revealed no chemical incompatibility between drug and the polymers.
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