Developing stem cell therapies: expansion strategies and lessons learned

Abstract

The field of mesenchymal stromal cell therapy for critically ill patients has been evolving rapidly. In this article, Corning Field Applications Scientist Catherine Siler will present tools and process design strategies for achieving consistent and efficient expansion of therapeutic cells, including scale-up and scale-out options and closed system designs. Then, Ottawa Hospital Research Institute scientists Shirley Mei and Josée Champagne will put the technology in context by discussing how their team translated a mesenchymal stromal therapy manufacturing process from the preclinical laboratory to a GMP setting.