Developing Flexible Carbon Nitride Quantum Dots Decorated Polyaniline Nanocomposite Layer for a Non-Invasive Wearable Sweat Biosensor for Glucose Monitoring

Abstract

Understanding dynamic biomarker fluctuations, particularly glucose, is vital for early diabetes therapy. Novel non-invasive wearable sweat biosensors are gaining appeal, enabling constant severity monitoring. Nevertheless, the key challenges are that multiplexed motions may result in undesirable metal cracking by the rigid electrocatalytic layer, leading to decreased sensitivity and stability. In this work, we designed carbon nitride quantum dots (CNQDs) decorated polyaniline (PANI) nanocomposite to realize flexible wearable biosensors with high detection accuracy. Upon the enhanced electron transfer by CNQDs, CNQDs/PANI nanocomposite offers greater sensitivity in H2O2 detection compared to pristine PANI, resulting in a sensitivity of 37.21 μA mM-1 cm-2. Therefore, after the glucose oxidase (GOx) immobilization, GOx/CNQDs/PANI-based biosensors is expected to show excellent performance for glucose detection in artificial sweat. Figure 1