Abstract
Background: Oral cancer is the sixth most common cancer globally; however, the incidence is much higher in the developing countries, including Pakistan, India, Sri Lanka. The etiology of oral cancer is multifactorial with majority of the cases attributable to separate and combined use of tobacco (smoked and smokeless), excessive alcohol consumption, betel quid, and betel quid substitutes. Among this, Kharra chewing (areca nut and tobacco) is the most prevalent addiction and the most common risk factors of oral cancer in central India.
 Objectives: To evaluate the risk of oral cancer associated with kharra users and non-tobacco user. To evaluate the association for the risk factors of oral cancer with kharra and non-tobacco user.
 Methodology: A hospital based case control study will be carry out in the study, the study will be conducted among the patient who had confirmed diagnosis of oral cancer and visited the hospital in AVBRH and SPDC Sawangi (Meghe) Wardha. Non- probability convenient sampling technique will be used for selecting the sample. The structured questionnaire will be used for collection of the data.
 Expected Results: This study is mainly planned to evaluate the effects of Kharra chewing on oral cancer risk with the help of structured questionnaire. Hence, it is expected to identify the effects of Kharra chewing on the risk of oral cancer.
Highlights
Kharra chewing is the most prevalent addiction in central India
Expected Results: This study is mainly planned to evaluate the effects of Kharra chewing on oral cancer risk with the help of structured questionnaire
It is expected to identify the effects of Kharra chewing on the risk of oral cancer
Summary
Kharra chewing (areca nut and tobacco) is the most prevalent addiction in central India. Several epidemiological and experimental investigations have established that quid chewing causes oral and oropharyngeal cancer, interferes with the microbial mechanism of neutrophils, and inhibits protein synthesis and attachment of fibroblasts. This in turn promotes bacterial colonization and periodontal infection. Kharra chewing (areca nut and tobacco) is the most prevalent addiction and the most common risk factors of oral cancer in central India. Objectives: To evaluate the risk of oral cancer associated with kharra users and non-tobacco user. To evaluate the association for the risk factors of oral cancer with kharra and non-tobacco user. Methodology: A hospital based case control study will be carry out in the study, the study will be conducted among the patient who had confirmed diagnosis of oral cancer and visited the hospital in Lalnunsanga et al.; JPRI, 33(60B): 3821-3826, 2021; Article no.JPRI.80061
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