Abstract
In order to establish and standardize the rabbit rib segmental bone defect model, it is of vital importance to determine rabbit rib critical size defect (CSD). According to the general time needed for spontaneous long-bone regeneration, three-month observation period was set to determine the CSD. The rabbit rib segmental bone defects with different sizes from 1 to 5 cm with or without periosteum were performed in the eighth rib of 4-month-old male New Zealand rabbits and underwent X-ray examinations at the 4th, 8th and 12th weeks postoperatively. The gross and histological examinations at postoperative week 12 were evaluated, which showed that the critical sizes in the rabbit rib models with and without periosteum were 5 and 2 cm, respectively. This study provides prerequisite data for establishing rabbit rib CSD model and evaluating bone materials using this model.
Highlights
Autologous rib is one of the most widely used bone autografts for repairing large segmental bone defects in clinic
In order to establish and standardize the rabbit rib segmental bone defect model, it is of vital importance to determine rabbit rib critical size defect (CSD)
This study provides prerequisite data for establishing rabbit rib CSD model and evaluating bone materials using this model
Summary
Autologous rib is one of the most widely used bone autografts for repairing large segmental bone defects in clinic. In order to evaluate and test the potential applications of all kinds of bone substitute materials in rib defect repair and inducing injured rib regeneration, an ideally canonical rib critical size defect (CSD) model should be established initially. No literatures were reported on the determination of critical size for rabbit rib defects. In this work, we developed a rabbit rib CSD model and determined the surgical procedure and critical size values, which will be able to provide a reference for the mechanism study on rabbit rib defect repair and future rib defect repair and the CSDs of human rib segmental defects. In the case of rabbit rib, two different CSDs about periosteum were considered
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